As I was clearing out my fridge last week, I stumbled upon a treasure trove of leftovers just waiting for a delicious revival. That’s when the idea struck me: a Meat Lovers Pizza Casserole that combines all that savory goodness into one cozy dish! Ready in just 35 minutes, this family-friendly casserole takes the hassle out of dinner prep while keeping everyone satisfied. It’s not only quick to prepare but also freezer-friendly, making it perfect for busy weeknights or game day gatherings. Load it up with your favorite meats like ground beef and pepperoni, and feel free to mix in any veggies you have on hand. The result is a warm, cheesy delight that might just become your new weeknight staple. What combinations will you dream up for your version?

What makes this casserole a must-try?
Quick and Easy: With just 35 minutes from start to finish, your family will be enjoying a scrumptious meal in no time.
Hearty and Satisfying: Packed with lean ground beef, savory pork sausage, and zesty pepperoni, this dish delivers a meat lover’s dream in every bite.
Freezer-Friendly: Make it ahead of time! Simply prepare and freeze before baking for an easy dinner solution on hectic nights.
Customizable: Use whatever meats or veggies you have, allowing you to tailor the recipe to your family’s tastes, just like in my Salisbury Meatballs and Mashed Potatoes recipe!
Crowd-Pleaser: Perfect for family dinners or game day gatherings, this comforting casserole is guaranteed to impress guests of all ages!
Delicious Texture: Enjoy a crispy crust that bursts with gooey, melted cheese and a flavorful filling—every slice is a delightful experience!
Meat Lovers Pizza Casserole Ingredients
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For the Meat Mixture
• Lean Ground Beef – Supports a hearty flavor profile; feel free to swap in ground turkey for a lighter dish.
• Pork Sausage – Adds a rich, savory element; consider Italian chicken sausage for a leaner version.
• Chopped Pepperoni – Brings a classic pizza taste; optional additions can include crumbled bacon or mushrooms for extra flavor. -
For the Sauce
• All-Purpose Flour – Acts as a thickener to create a robust sauce; no substitutes required here.
• Italian Seasoning (4 tsp, divided) – Imparts essential Italian flavors; using fresh herbs can brighten the taste.
• Tomato Basil Pasta Sauce (26 oz) – This sauce serves as the flavorful base; marinara or arrabbiata can be great alternatives. -
For the Cheese Layer
• Shredded Mozzarella Cheese (2 cups) – Guarantees a gooey, cheesy top; choosing freshly shredded enhances the melt quality.
• Grated Parmesan Cheese (3 Tbsp) – Adds a delightful salty kick; can be omitted for a milder option. -
For the Crust
• Refrigerated Pizza Crust Dough (13.8 oz) – Forms that crucial top layer; using biscuit dough will create a fluffier texture.
• Olive Oil (1 Tbsp) – Brushed on the crust for flavor and browning; swapping with melted butter is also a tasty choice.
This Meat Lovers Pizza Casserole is not only a recipe to cherish but also a family favorite waiting to inspire dinner time creativity!
Step‑by‑Step Instructions for Meat Lovers Pizza Casserole
Step 1: Preheat and Prepare
Start by preheating your oven to 425ºF (220ºC). While the oven heats, grab a 9×13-inch baking dish and spray it with cooking spray to prevent sticking. This quick preparation helps the Meat Lovers Pizza Casserole to cook evenly and ensures easy removal once baked.
Step 2: Brown the Meats
In a large skillet, heat over medium-high heat and add the lean ground beef and pork sausage. Cook the meat mixture for about 5-7 minutes, stirring frequently until it’s well browned. Drain any excess fat carefully, as this helps avoid a greasy casserole and keeps the flavors rich and hearty.
Step 3: Add Flavor and Thicken
Next, stir in the chopped pepperoni, flour, and 3 teaspoons of Italian seasoning to the skillet. Mix everything thoroughly and cook for an additional 2-3 minutes until the ingredients are well blended and the flour is slightly cooked. This forms a flavorful base for the hearty Meat Lovers Pizza Casserole.
Step 4: Incorporate the Sauce
Pour in the tomato basil pasta sauce and bring the mixture to a gentle boil. Stir well, allowing the sauce to meld with the meat and seasoning for about 2 minutes. Once it’s bubbling nicely, remove the skillet from the heat so the flavors can settle before layering.
Step 5: Assemble the Casserole
Spoon the savory meat mixture into the prepared baking dish, spreading it out evenly. Next, layer 1½ cups of shredded mozzarella cheese on top, ensuring a generous layer for that gooey, cheesy finish. This step sets the stage for creating a delightful Meat Lovers Pizza Casserole everyone will enjoy.
Step 6: Prepare the Crust
Unroll the refrigerated pizza crust dough and carefully place it over the cheese layer in the baking dish. Press down slightly to seal the ingredients below. Brush the crust with olive oil to enhance the browning and flavor, then sprinkle the remaining Italian seasoning and grated Parmesan cheese over the top.
Step 7: Bake to Perfection
Place the casserole in the preheated oven and bake for 20-25 minutes, or until the crust is golden brown and the cheese is bubbling. Keep an eye on it towards the end to ensure the crust achieves that perfect golden hue, which is key to enjoying this Meat Lovers Pizza Casserole.
Step 8: Cool and Serve
Once out of the oven, let the casserole cool for about 5 minutes. This resting period makes slicing easier and allows the flavors to settle beautifully. Cut into squares and serve warm, savoring the comforting, cheesy goodness that makes this dish a family favorite!

Make Ahead Options
These Meat Lovers Pizza Casserole preparations are a lifesaver for busy weeknights! You can prepare the entire dish up to 24 hours in advance, stopping just before adding the pizza crust. Simply layer the meat mixture and cheese in a greased baking dish, then cover tightly with plastic wrap to maintain freshness. When you’re ready to enjoy, remove the dish from the refrigerator, allow it to rest at room temperature for about 30 minutes, and then top with the crust and apply olive oil before baking. This method ensures your casserole is just as delicious, with flavors that meld beautifully over time, ready to impress your family with minimal effort!
How to Store and Freeze Meat Lovers Pizza Casserole
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Fridge: Store leftovers in an airtight container for up to 4 days. This keeps your Meat Lovers Pizza Casserole fresh and ready for quick reheating.
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Freezer: Wrap tightly in plastic wrap and aluminum foil, then freeze for up to 2 months. Thaw overnight in the fridge before reheating for best results.
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Reheating: To reheat, place the casserole in a preheated oven at 350ºF (175ºC) for about 20-25 minutes, or until heated through. Add a sprinkle of fresh cheese for an extra melty topping!
Helpful Tricks for Meat Lovers Pizza Casserole
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Prevent Greasiness: Drain the cooked meat thoroughly to eliminate excess grease, ensuring a satisfying and flavorful casserole without the unwanted oiliness.
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Crispier Crust: For a golden, crispy top, consider prebaking the pizza crust for 5 minutes before layering. This step enhances the texture of the Meat Lovers Pizza Casserole.
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Easier Slicing: Allow the casserole to rest for a few minutes after baking. This not only makes slicing easier but also helps the layers set up nicely.
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Make Ahead Option: Prepare the dish up until adding the crust, cover, and refrigerate for later baking when you’re short on time. This makes dinner prep a breeze!
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Customizable Ingredients: Feel free to swap in your family’s favorite meats or vegetables to personalize the recipe. Get creative and make your Meat Lovers Pizza Casserole truly your own!
What to Serve with Meat Lovers Pizza Casserole
A comforting casserole deserves to be paired with delightful sides that elevate the whole dining experience.
- Garlic Bread: Perfect for sopping up any delicious sauce and adding a crunchy texture that complements the casserole’s gooeyness.
- Caesar Salad: Crisp romaine, crunchy croutons, and creamy dressing provide a refreshing contrast to the rich, hearty casserole.
- Roasted Vegetables: A colorful medley of seasonal vegetables adds a healthy touch and balances the savory flavors in your meal.
- Italian Antipasto Platter: Combine cured meats, olives, and cheeses to spark vibrant flavors and indulge in a delightful snacking experience pre-dinner.
- Cola or Root Beer: A glass of fizzy soda cuts through the richness of the casserole and adds a fun, nostalgic touch to dinner.
- Cheesecake Bites: For dessert, these sweet, creamy morsels offer a delightful finish, providing an irresistible contrast to your hearty main course.
- Pesto Pasta Salad: A side of pasta salad mixed with fragrant pesto brings layers of flavors and a refreshing quality to your dinner table.
- Zucchini Chips: Baked until crispy, these veggie chips serve as a lighter option that pairs well with the casserole’s meaty richness.
These pairings will enhance your meal, ensuring every bite is packed with flavor and texture that everyone will love!
Meat Lovers Pizza Casserole Variations
Feel free to unleash your creativity and customize your Meat Lovers Pizza Casserole with these friendly suggestions that will tantalize your taste buds!
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Spicy Kick: Add crushed red pepper flakes or use spicy sausage for an extra zing. This will elevate your casserole’s flavor profile, making each bite exciting!
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Veggie Boost: Incorporate sliced bell peppers or onions into the meat mixture for a pop of color and nutrition. Not only will this enhance flavors, but it also adds a wonderful crunch!
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Gluten-Free: Switch to gluten-free pizza dough to accommodate dietary needs without sacrificing taste. Your family won’t even notice the difference!
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Cheesy Explosion: Experiment with different cheese types! Try adding pepper jack or gouda for a unique flavor twist. The extra meltiness will delight every cheese lover!
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Crispy Top: Consider using biscuit dough instead of pizza crust for a fluffier and more decadent topping. It creates an entirely different texture that’s equally satisfying.
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Fresh Herb Flavor: Substitute dried Italian seasoning with fresh herbs like basil or oregano for a vibrant burst of flavor. The freshness will surprise your guests!
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Meat Medley: Mix in other meats such as crumbled bacon or ham to amp up the protein content and try different combinations of meaty goodness. Each variation becomes a new experience!
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Saucy Variations: Use a different pasta sauce like marinara or arrabbiata for a new taste adventure. Switching up the sauce can enhance the overall flavor and keep things interesting!
You can take your Meat Lovers Pizza Casserole to delightful heights, just like my Pepperoni Pizza Bombs or a comforting Chicken Stuffing Casserole! Enjoy tailoring this dish to match your family’s tastes!

Meat Lovers Pizza Casserole Recipe FAQs
What kind of meat should I use for the Meat Lovers Pizza Casserole?
Absolutely! For a classic approach, lean ground beef, pork sausage, and chopped pepperoni work wonderfully. If you want to lighten it up, feel free to substitute ground turkey for the beef and Italian chicken sausage for the pork. You can even mix in crumbled bacon or mushrooms for that extra deliciousness!
How should I store leftovers of Meat Lovers Pizza Casserole?
To keep your leftovers fresh, simply place them in an airtight container in the fridge. Enjoy within 4 days for the best flavor. Just reheat in the oven at 350ºF until warmed through—it’s the perfect quick meal for lunch or dinner!
Can I freeze Meat Lovers Pizza Casserole?
Very much so! Wrap individual portions in plastic wrap and then in aluminum foil to protect against freezer burn. You can store it for up to 2 months. When you’re ready to enjoy, thaw it in the fridge overnight, then reheat in the oven—just like fresh from the oven!
What should I do if my casserole turns out greasy?
If you find your casserole a bit greasy, it’s most likely due to excess fat in the meat. To avoid this, be sure to drain the meat thoroughly after browning and consider using leaner meat options. Also, pre-baking the pizza crust for about 5 minutes can help create a barrier that absorbs some of that grease.
What dietary considerations should I be aware of with this casserole?
Excellent question! This dish can easily accommodate different diets. For gluten-free eaters, simply swap the refrigerated pizza crust with gluten-free dough. Always check your ingredients for common allergens, especially if you’re serving guests; the sausage and pepperoni can contain gluten, dairy, or other allergens. Make sure to keep your loved ones’ needs in mind!
Can I make this casserole ahead of time?
Definitely! You can prepare everything up to the point of adding the pizza crust. Just cover the baking dish and refrigerate it for up to a day. When you’re ready to eat, simply bake it as directed. It’s a fantastic option for busy nights when you want a home-cooked meal without all the fuss!

Savory Meat Lover Pizza Casserole Ready in Just 35 Minutes
Ingredients
Equipment
Method
- Preheat your oven to 425ºF (220ºC) and spray a 9x13-inch baking dish with cooking spray.
- In a large skillet, add the lean ground beef and pork sausage. Cook for about 5-7 minutes until browned and drain excess fat.
- Stir in the chopped pepperoni, flour, and 3 teaspoons of Italian seasoning. Cook for an additional 2-3 minutes.
- Pour in the tomato basil pasta sauce and bring to a gentle boil for about 2 minutes.
- Spoon the meat mixture into the baking dish and layer with 1½ cups of shredded mozzarella cheese.
- Place the refrigerated pizza crust dough over the cheese layer and brush with olive oil. Sprinkle remaining Italian seasoning and Parmesan cheese.
- Bake for 20-25 minutes until the crust is golden brown and the cheese is bubbling.
- Let the casserole cool for about 5 minutes before slicing and serving warm.

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